1. Introduction to 4-Iodobenzoyl Chloride
Product Name: 4-Iodobenzoyl Chloride
CAS Number: 1711-02-0
Chemical Formula: C7H4ClIO
Molecular Weight: 266.47 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC)
Storage: Store at 2-8°C in a tightly sealed container, protected from light and moisture.
2. Applications of 4-Iodobenzoyl Chloride
4-Iodobenzoyl Chloride is a versatile intermediate in organic synthesis, widely used in:
- Pharmaceuticals: Synthesis of active pharmaceutical ingredients (APIs), particularly in antibiotics and anticancer agents.
- Agrochemicals: Production of herbicides and pesticides.
- Material Science: Precursor for polymers, liquid crystals, and specialty coatings.
- Chemical Research: Cross-coupling reactions, Suzuki-Miyaura reactions, and iodination processes.
3. Usage Guidelines
Safety Precautions:
- Wear PPE (gloves, goggles, lab coat) to avoid skin/eye contact.
- Use in a well-ventilated area or fume hood.
- Avoid inhalation of vapors or dust.
Handling:
- Dissolve in inert solvents like dichloromethane or THF before reaction.
- Stabilize with dry conditions to prevent hydrolysis.
Storage: Keep under inert gas (argon/nitrogen) for long-term stability.
4. Case Studies
Case Study 1: Synthesis of 4-Iodobenzoic Acid Derivatives
4-Iodobenzoyl Chloride was hydrolyzed under alkaline conditions to produce 4-iodobenzoic acid (yield: 92%), a key intermediate in radiopharmaceuticals.
Case Study 2: Palladium-Catalyzed Cross-Coupling
Used in a Suzuki-Miyaura reaction with arylboronic acids to synthesize biaryl compounds for OLED materials, achieving >95% purity.
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