Our product is high - quality Resiniferatoxin with the CAS number 57444 - 62 - 9. Resiniferatoxin is a highly potent capsaicin analog. It is a white to off - white powder. The purity of our product is rigorously tested, ensuring a high - quality standard. The molecular formula of Resiniferatoxin is C₃₇H₅₀O₁₃, and its molecular weight is approximately 702.79 g/mol. It is sparingly soluble in water but soluble in organic solvents such as ethanol and DMSO. The product is stored under specific temperature and humidity conditions to maintain its stability and effectiveness. We offer it at the best price in the market, providing you with excellent value for your money.
Resiniferatoxin has a wide range of applications in scientific research and the medical field. In scientific research, it is often used as a tool to study the TRPV1 (transient receptor potential cation channel subfamily V member 1) receptor. TRPV1 is involved in pain sensation, thermoregulation, and other physiological processes. By using Resiniferatoxin to activate TRPV1, researchers can gain a better understanding of its function and the associated signaling pathways.
In the medical field, Resiniferatoxin shows great potential as a pain - relieving agent. It can selectively desensitize pain - sensing nerve fibers, which makes it a promising candidate for the treatment of chronic pain conditions such as neuropathic pain, cancer - related pain, and pain associated with spinal cord injury. Additionally, it may also have applications in the treatment of overactive bladder, as it can modulate the nerve activity in the bladder.
When using Resiniferatoxin, strict safety precautions should be followed. Since it is a highly potent compound, it should be handled by trained personnel in a well - equipped laboratory environment. First, it needs to be properly dissolved in an appropriate solvent. For example, if using ethanol or DMSO, the recommended concentration for initial experiments should be carefully determined according to the specific research or application requirements.
For in - vitro studies, the solution can be added to cell cultures at the appropriate concentration. The incubation time and temperature also need to be optimized based on the experimental design. In in - vivo studies, the administration route (such as subcutaneous, intrathecal, or intra - venous injection) should be selected carefully, and the dosage should be calculated precisely according to the animal model and the purpose of the study.
Case 1: Neuropathic Pain Research
A research team was studying a rat model of neuropathic pain. They prepared a Resiniferatoxin solution in DMSO at a concentration of 1 μM. The solution was then administered intrathecally to the rats. After the administration, they observed a significant reduction in pain - related behaviors in the rats over a period of several weeks. The researchers also found that Resiniferatoxin selectively targeted the TRPV1 - expressing nerve fibers in the spinal cord, leading to desensitization and a decrease in pain signaling.
Case 2: Overactive Bladder Treatment
In a clinical trial, patients with overactive bladder were treated with Resiniferatoxin. A low - dose solution was instilled into the bladder. After treatment, many patients reported a significant improvement in their symptoms, including a decrease in the frequency of urination and urgency. The treatment was well - tolerated, and there were no serious adverse effects reported. This study demonstrated the potential of Resiniferatoxin in treating overactive bladder.
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Este é o William, Diretor Executivo da Zhishang Chemical Co., Ltd.
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