High Quality Glycocholic acid with the CAS number 475 - 31 - 0 is a significant bile acid conjugate. Chemically, it is the N - choloyl - glycine conjugate, resulting from the conjugation of cholic acid with glycine. This product is known for its high purity and is offered at the best price in the market.
Its molecular formula is C₂₆H₄₃NO₆, and it has a molecular weight of approximately 465.62 g/mol. Physically, it appears as a white to off - white crystalline powder. It is sparingly soluble in water but more soluble in ethanol and methanol. The melting point of glycocholic acid is around 164 - 166 °C. It has a specific rotation of [α]₂₀D = +30 to +35° (c = 1, ethanol).
In the pharmaceutical industry, glycocholic acid plays a crucial role. It is used as a solubilizing agent for poorly water - soluble drugs. By forming micelles in solution, it can increase the solubility and bioavailability of hydrophobic drugs, which is essential for the development of oral and parenteral drug formulations. Additionally, it can be used as a tool in drug absorption studies due to its ability to interact with cell membranes and affect the permeability of drugs across the intestinal epithelium.
In the field of biochemistry and cell biology, glycocholic acid is used as a substrate for studying bile acid - related enzymes and transporters. It can help researchers understand the metabolic pathways of bile acids in the liver and intestine, which is relevant to the study of liver diseases, such as cholestasis and fatty liver disease.
In the food industry, it can be used as an emulsifier and flavor enhancer. Its amphiphilic nature allows it to stabilize oil - in - water emulsions, improving the texture and stability of food products. It can also contribute to the characteristic flavor of some fermented foods.
When using glycocholic acid in a laboratory or industrial setting, first, it is important to handle it with appropriate safety precautions. Wear gloves, safety glasses, and a lab coat to avoid direct contact with the skin and eyes. If inhaled or ingested, it may cause irritation, so ensure good ventilation in the working area.
For solubilizing drugs, prepare a stock solution of glycocholic acid in a suitable solvent, such as ethanol or methanol. The concentration of the stock solution can be adjusted according to the solubility requirements of the drug. Then, add the drug to the solution and mix thoroughly. The mixture can be further diluted with an aqueous buffer if needed.
In biochemical assays, prepare the reaction mixture containing the appropriate concentration of glycocholic acid, enzymes, and other necessary reagents according to the experimental protocol. Incubate the mixture at the optimal temperature and time for the reaction to occur. Monitor the reaction progress using appropriate analytical methods, such as spectrophotometry or chromatography.
Case 1: Pharmaceutical Drug Solubilization
A pharmaceutical company was developing a new oral anti - cancer drug that had extremely low water solubility. By using glycocholic acid as a solubilizing agent, they were able to increase the solubility of the drug by more than 10 - fold. They prepared a formulation with a specific ratio of glycocholic acid and the drug, and in pre - clinical studies, the bioavailability of the drug was significantly improved compared to the non - solubilized form. This led to better therapeutic effects in animal models.
Caso 2: Investigação bioquímica
A research team was studying a bile acid transporter in the liver. They used glycocholic acid as a substrate to measure the transport activity of the transporter. By incubating liver cells with different concentrations of glycocholic acid and monitoring the uptake and efflux of the acid, they were able to characterize the kinetic properties of the transporter. This research provided valuable insights into the mechanism of bile acid transport in the liver and potential therapeutic targets for liver diseases.
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Este é o William, Diretor Executivo da Zhishang Chemical Co., Ltd.
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