The product, High Quality TMSOTF / Trimethylsilyl Trifluoromethanesulfonate with the CAS number 27607 - 77 - 8, is a high - performance chemical compound. It is renowned for its low price, making it an attractive option for various industrial and research applications.
Chemical Formula: C₄H₉F₃O₃SSi
Molecular Weight: Approximately 234.26 g/mol
Appearance: Usually a colorless to light - yellow liquid
Boiling Point: Around 140 - 142°C at 760 mmHg
Density: About 1.277 g/mL at 25°C
Flash Point: 38°C
TMSOTF is widely used in organic synthesis. It serves as a powerful silylating agent, which is crucial in protecting hydroxyl, carboxyl, and other functional groups during multi - step chemical reactions. By protecting these groups, chemists can selectively perform reactions on other parts of the molecule without affecting the protected groups.
In the field of pharmaceutical research, TMSOTF is used to modify the structure of drug candidates. This modification can enhance the drug's solubility, stability, and bioavailability, which are all important factors in the development of effective drugs.
It is also used in the synthesis of advanced materials. For example, in the preparation of liquid crystals, TMSOTF can be used to introduce specific functional groups, thereby improving the performance of liquid crystals.
When using TMSOTF, proper safety precautions should be taken. It should be handled in a well - ventilated area, preferably in a fume hood, as it can release harmful vapors. Gloves, goggles, and a lab coat should be worn to prevent direct contact with the skin and eyes.
In a typical organic synthesis reaction, TMSOTF is usually added drop - wise to the reaction mixture under an inert atmosphere, such as nitrogen or argon. The reaction temperature and time need to be carefully controlled according to the specific reaction requirements. After the reaction is completed, appropriate purification steps, such as extraction, filtration, and distillation, are usually carried out to obtain the desired product.
Case 1: In a pharmaceutical R & D project, researchers aimed to modify a drug candidate to improve its solubility. They used TMSOTF to silylate the hydroxyl groups of the drug molecule. The reaction was carried out in a solvent mixture of dichloromethane and triethylamine at 0°C. After the reaction, the silylated product was purified by column chromatography. The solubility test showed that the solubility of the modified drug in water increased significantly, which was beneficial for further in - vivo studies.
Case 2: In the synthesis of a novel liquid crystal material, TMSOTF was used to introduce a trifluoromethyl - containing group into the molecular structure. The reaction was carried out in a high - boiling - point solvent under reflux conditions. After purification, the prepared liquid crystal material showed improved electro - optical properties, such as faster response time and higher contrast ratio, making it suitable for high - performance display applications.
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