Lithocholic acid, with the CAS number 434 - 13 - 9, is a secondary bile acid. Chemically, it belongs to the class of steroids. Its molecular formula is C24H40O3, and it has a molecular weight of approximately 376.57 g/mol. This high - quality lithocholic acid is available at a low price, making it an attractive option for various research and industrial applications. It appears as a white to off - white crystalline powder. It has a melting point in the range of 188 - 190°C, and it is sparingly soluble in water but soluble in organic solvents such as ethanol and chloroform.
1. **Medical Research**: Lithocholic acid has been the subject of extensive medical research. It is involved in the study of bile acid metabolism and its role in liver diseases. Researchers use it to understand the pathogenesis of cholestatic liver diseases, as abnormal levels of lithocholic acid are often associated with these conditions.
2. **Pharmaceutical Industry**: It can be used as a starting material or intermediate in the synthesis of certain pharmaceuticals. Some drugs are designed to regulate bile acid levels, and lithocholic acid can contribute to the development of such medications.
3. **Biological Studies**: In cell culture and biological studies, lithocholic acid is used to investigate its effects on cell growth, apoptosis, and signal transduction pathways. It can help researchers understand the complex biological processes in the body.
1. **In Research Laboratories**: When using lithocholic acid in a research setting, it is usually first dissolved in an appropriate organic solvent such as ethanol or DMSO (dimethyl sulfoxide) to prepare a stock solution. The stock solution should be stored at a low temperature, typically - 20°C, to maintain its stability. The appropriate concentration of the working solution can be prepared by diluting the stock solution with the relevant buffer or medium according to the experimental requirements.
2. **In Industrial Synthesis**: In the pharmaceutical and chemical industries, lithocholic acid should be handled in a well - ventilated area following strict safety procedures. The reaction conditions, such as temperature, pressure, and reaction time, need to be carefully controlled during the synthesis process to ensure the quality and yield of the final product.
1. **Case 1: Liver Disease Research**
A research team was studying the mechanism of cholestatic liver disease. They used lithocholic acid to induce a cholestasis model in cell cultures. By treating hepatocytes with different concentrations of lithocholic acid, they observed changes in cell viability, bile acid transport protein expression, and oxidative stress markers. The results showed that high concentrations of lithocholic acid could lead to significant cell damage and abnormal bile acid metabolism, which provided important insights into the pathogenesis of cholestatic liver diseases.
2. **Case 2: Pharmaceutical Synthesis**
A pharmaceutical company was developing a new drug to treat bile acid - related disorders. They used lithocholic acid as an intermediate in the synthesis process. Through a series of chemical reactions, including oxidation and esterification, they successfully converted lithocholic acid into the target compound. The new drug showed promising results in pre - clinical trials, indicating the potential of lithocholic acid in pharmaceutical development.
If you have any questions about our high - quality lithocholic acid or need further technical support, please feel free to contact us. Our email address is info@vivalr.com, and our phone number is (86) 15866781826.
Este é o William, Diretor Executivo da Zhishang Chemical Co., Ltd.
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