The product, Factory Supply 1,1′-Carbonyldiimidazole with CAS number 530 - 62 - 1, is a crucial chemical compound in the industry. It typically comes as a white to off - white crystalline powder. The molecular formula of 1,1′-Carbonyldiimidazole is C7H6N4O, and its molecular weight is approximately 162.15 g/mol.
It has a melting point in the range of 116 - 122°C. This compound is highly soluble in common organic solvents such as dichloromethane, tetrahydrofuran, and acetonitrile, but it reacts with water and alcohols. The purity of the product can usually reach over 98%, ensuring high - quality performance in various applications.
1,1′-Carbonyldiimidazole is widely used in organic synthesis. One of its primary applications is in the formation of amide bonds. It can activate carboxylic acids, making them more reactive towards amines. This reaction is mild and selective, often used in peptide synthesis where the preservation of other functional groups is crucial.
It is also used in the synthesis of esters, carbonates, and urethanes. In the pharmaceutical industry, it serves as an important intermediate in the production of various drugs. Additionally, in the field of polymer chemistry, it can be used as a coupling agent to modify polymer chains and improve their performance.
When using 1,1′-Carbonyldiimidazole, it is essential to follow strict safety procedures. First, ensure that all equipment is dry, as the compound reacts with water. Wear appropriate personal protective equipment, including gloves, safety glasses, and a lab coat.
For amide bond formation, dissolve the carboxylic acid in an appropriate anhydrous organic solvent, such as dichloromethane. Add 1,1′-Carbonyldiimidazole slowly to the solution while stirring at a low temperature (usually 0 - 5°C). After the activation step is complete (usually indicated by the disappearance of the starting acid), add the amine drop - wise. The reaction can then be allowed to proceed at room temperature or with gentle heating, depending on the nature of the reactants.
After the reaction is complete, the product can be isolated by standard purification methods such as extraction, chromatography, or recrystallization.
Peptide Synthesis: In a research project aiming to synthesize a bioactive peptide, 1,1′-Carbonyldiimidazole was used to activate the carboxyl group of the N - protected amino acid. A solution of the protected amino acid in anhydrous THF was cooled to 0°C, and 1,1′-Carbonyldiimidazole was added. After 30 minutes of stirring, the next amino acid in the peptide sequence was added. The reaction mixture was then stirred at room temperature overnight. After purification by reversed - phase HPLC, the desired peptide was obtained in good yield with high purity.
Síntese de intermediários farmacêuticos: A pharmaceutical company was synthesizing a new anti - inflammatory drug. 1,1′-Carbonyldiimidazole was used to form an ester intermediate. The carboxylic acid precursor was dissolved in dichloromethane, and 1,1′-Carbonyldiimidazole was added. After activation, an alcohol was introduced, and the reaction was carried out at reflux for several hours. The resulting ester was further transformed into the final drug product through subsequent chemical steps.
If you have any questions or need further information about our Factory Supply 1,1′-Carbonyldiimidazole CAS 530 - 62 - 1, please feel free to contact us. Our email address is info@vivalr.com, and our phone number is (86) 15866781826.
Este é o William, Diretor Executivo da Zhishang Chemical Co., Ltd.
Bem-vindo a visitar a nossa fábrica. Como o principal fabricante de produtos químicos, temos nos esforçado para a qualidade do produto, inovação, P & D e atendimento ao cliente nos últimos 7 anos. Nos próximos 10 anos ou mais, estamos empenhados em nos tornarmos o fornecedor de produtos químicos mais confiável do mundo, criando uma marca internacional bem conhecida e de confiança dos clientes, com o espírito de "um metro de largura, dez mil metros de profundidade", continuamos a nos concentrar na pesquisa e desenvolvimento de produtos, continuamos a nos concentrar no atendimento ao cliente, continuamos a melhorar o sistema de serviço da cadeia de suprimentos, para criar uma equipe profissional de serviços de fornecimento de produtos químicos, para alcançar uma cooperação de longo prazo ganha-ganha. Por favor, não hesite em contactar-nos se tiver alguma dúvida.
Portuguese 
English (United States) 
English (Australia) 
Spanish