High Quality n - iodosuccinimide with the CAS number 516 - 12 - 1 is a chemical compound that has gained significant attention in various chemical industries due to its unique properties. The product is known for its high quality, which means it has a high degree of purity and consistent performance. It also comes at a low price, making it an economical choice for many users.
Chemically, n - iodosuccinimide has the molecular formula C₄H₄INO₂. It appears as a white to off - white crystalline powder. The melting point of this compound is typically around 200 - 202°C. It is sparingly soluble in water but soluble in some organic solvents such as acetone, chloroform, and ethyl acetate. The density of n - iodosuccinimide is approximately 2.19 g/cm³.
n - iodosuccinimide has a wide range of applications in the field of organic synthesis. It is commonly used as an iodinating agent. In organic reactions, it can introduce iodine atoms into various organic molecules, which is crucial for the synthesis of many pharmaceutical intermediates, agrochemicals, and advanced materials.
For example, in the synthesis of iodine - containing heterocyclic compounds, n - iodosuccinimide can react with appropriate substrates to form new carbon - iodine bonds. These iodine - containing heterocycles are often used in the development of new drugs, as they can have unique biological activities.
It is also used in some oxidation reactions. In certain cases, it can act as an oxidant to convert alcohols to aldehydes or ketones under specific reaction conditions. This property makes it a valuable tool in the synthesis of fine chemicals and complex organic molecules.
When using High Quality n - iodosuccinimide, it is important to follow proper safety procedures. Always wear appropriate personal protective equipment, such as gloves and safety glasses, to avoid direct contact with the product. Since it is a chemical compound, inhalation of its dust should be avoided.
In a typical reaction, n - iodosuccinimide is usually added to a reaction mixture containing the substrate and an appropriate solvent. The reaction conditions, such as temperature, reaction time, and the amount of n - iodosuccinimide used, need to be carefully controlled according to the specific reaction requirements. For example, in an iodination reaction, the reaction temperature may range from room temperature to reflux conditions, depending on the reactivity of the substrate.
After the reaction is completed, the product can be separated and purified using common separation techniques, such as filtration, extraction, and chromatography. The choice of purification method depends on the nature of the product and the reaction by - products.
Case Study 1: Synthesis of an Iodine - Containing Pharmaceutical Intermediate
A research group was working on the synthesis of a new pharmaceutical intermediate. They used n - iodosuccinimide as an iodinating agent. In a round - bottom flask, they added 10 grams of the substrate dissolved in 50 mL of acetone. Then, they slowly added 8 grams of n - iodosuccinimide at room temperature. The reaction mixture was stirred for 4 hours. After the reaction, they added water to the mixture and extracted the product with ethyl acetate. The organic layer was washed with brine and dried over anhydrous sodium sulfate. After evaporation of the solvent, they obtained the desired iodine - containing intermediate with a yield of 80%. This intermediate was further used in the synthesis of the final drug molecule.
Case Study 2: Oxidation of an Alcohol
A chemical company was interested in converting a particular alcohol to the corresponding aldehyde. They used n - iodosuccinimide as an oxidant. They dissolved 15 grams of the alcohol in 100 mL of chloroform in a flask. Then, they added 12 grams of n - iodosuccinimide and heated the reaction mixture under reflux for 6 hours. After the reaction, they cooled the mixture and filtered it to remove the solid by - products. The filtrate was washed with water and dried. After purification by column chromatography, they obtained the aldehyde with a yield of 75%.
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