High Quality Polydioxanone with the CAS number 31621 - 87 - 1 is a synthetic, absorbable polymer. It is a colorless to pale - yellow solid, typically in the form of granules or powder. The polymer has a high molecular weight, which endows it with excellent mechanical properties. Its melting point ranges from 105 - 110°C, and it has a density of approximately 1.35 g/cm³. The product is highly soluble in some organic solvents such as chloroform and dichloromethane but insoluble in water. It is known for its biocompatibility and biodegradability, which makes it a popular choice in many medical and industrial applications.
In the medical field, Polydioxanone is widely used in surgical sutures. Due to its excellent tensile strength and slow absorption rate (about 180 days), it can maintain the wound closure for a sufficient time during the healing process. It is also used in tissue engineering scaffolds. The biocompatibility of this polymer allows cells to adhere and grow on it, promoting the regeneration of damaged tissues. In addition, it has potential applications in drug delivery systems. The polymer can encapsulate drugs and release them slowly over time, providing a controlled - release effect.
In the industrial sector, Polydioxanone can be used as a modifier in some polymer blends. It can improve the mechanical properties, such as toughness and flexibility, of the blends. It is also used in the production of some special - purpose films and fibers, where its biodegradability is highly valued.
When using Polydioxanone in medical applications like making surgical sutures, first, it needs to be melted at an appropriate temperature (around its melting point). Then, the molten polymer is extruded through a spinneret to form fibers of the desired diameter. These fibers are then further processed, such as being twisted and coated with a lubricant to improve their handling characteristics. When used in tissue engineering, the polymer can be fabricated into three - dimensional scaffolds using techniques like 3D printing or electrospinning. The scaffolds are then sterilized before being seeded with cells.
In industrial applications, when using it as a polymer modifier, it is typically mixed with other polymers in the molten state in a mixer or an extruder. The mixing ratio should be carefully controlled according to the desired properties of the final blend. For the production of films and fibers, the polymer is usually melted and then processed through a film - blowing or spinning process.
Case 1: A large - scale hospital used Polydioxanone surgical sutures in abdominal surgeries. The sutures showed excellent performance in terms of wound closure. Patients reported less pain and discomfort compared to traditional non - absorbable sutures. The slow absorption rate of the Polydioxanone sutures allowed the wounds to heal properly without the need for suture removal, reducing the risk of secondary infections. After 6 months of follow - up, the wound healing rate was significantly higher than that of the control group using non - absorbable sutures.
Case 2: A tissue engineering research team used Polydioxanone scaffolds to repair damaged cartilage in rabbits. The scaffolds were fabricated using 3D printing technology, which provided a highly porous structure for cell growth. After 12 weeks of implantation, histological analysis showed that the Polydioxanone scaffolds had effectively promoted the regeneration of cartilage tissue, and there was no obvious immune rejection reaction.
Case 3: An industrial company used Polydioxanone as a modifier in a polypropylene blend. The blend was used to produce automotive interior parts. The addition of Polydioxanone improved the impact resistance and flexibility of the polypropylene, making the parts more durable. The company reported an increase in customer satisfaction due to the improved quality of the products.
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