2-Oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine (CAS 26853-31-6) is a high-purity phospholipid widely used in pharmaceutical research, liposomal formulations, and membrane studies. This guide provides detailed insights into its specifications, applications, and best practices for optimal results.
Used in liposomal formulations to enhance solubility and bioavailability of hydrophobic drugs.
Critical for mimicking cell membranes in biophysical and biochemical research.
Applied in studies involving membrane protein interactions and signaling pathways.
Dissolve in chloroform/methanol (2:1 v/v) for stock solutions. Vortex thoroughly and store at -20°C.
Mix with cholesterol (55:45 molar ratio) and hydrate with PBS buffer. Use sonication or extrusion for uniform size.
Verify particle size via dynamic light scattering (DLS) and encapsulation efficiency via HPLC.
A 2023 study utilized CAS 26853-31-6 to encapsulate Doxorubicin, achieving 85% encapsulation efficiency and 48-hour sustained release in vitro. Tumor regression rates improved by 40% compared to free drug administration.
Researchers achieved 90% stability of G-protein coupled receptors (GPCRs) by incorporating this phospholipid into nanodiscs, enabling prolonged structural analysis.
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