High Quality Trans-4-tert-butylcyclohexanol CAS 21862-63-5: Product User Guide
Table of Contents
1. Product Information
Trans-4-tert-butylcyclohexanol (CAS 21862-63-5) is a high-purity organic compound widely used in chemical synthesis and pharmaceutical research. Key specifications include:
- Chemical Formula: C10H20O
- Molecular Weight: 156.27 g/mol
- Appearance: White crystalline powder
- Purity: ≥98% (HPLC)
- Storage: 2-8°C in airtight containers
2. Applications
Trans-4-tert-butylcyclohexanol is utilized in:
- Organic synthesis as a chiral building block.
- Pharmaceutical intermediates for drug development.
- Catalyst preparation in asymmetric reactions.
- Solvent or stabilizer in specialty chemical formulations.
3. Usage Instructions
Handling & Safety
- Wear PPE (gloves, goggles, lab coat).
- Use in a well-ventilated area or fume hood.
Preparation
- Dissolve in non-polar solvents (e.g., hexane, ethyl acetate).
- Optimal concentration: 0.1-1.0 M for reactions.
Storage
- Keep containers sealed to avoid moisture absorption.
- Store away from oxidizing agents.
4. Detailed Use Cases
Case 1: Asymmetric Synthesis Catalyst
Used as a chiral ligand in rhodium-catalyzed hydrogenation:
Rh(COD)₂BF₄ + Trans-4-tert-butylcyclohexanol → Active Catalyst
Yield: 92% enantiomeric excess (ee).
Case 2: Pharmaceutical Intermediate
Synthesis of antiviral drug precursors:
- Mix 5g Trans-4-tert-butylcyclohexanol with 20mL THF.
- Add 1.2 eq. borane-THF complex at 0°C.
- Stir for 4h at room temperature.