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5-Methyluridine CAS 1463-10-1: Technical Guide, Applications & Best Practices

1. Product Overview

5-Methyluridine (CAS 1463-10-1) is a modified nucleoside derivative with the following specifications:

Chemical Name: 5-Methyluridine
CAS Number: 1463-10-1
Molecular Formula: C10H14N2O6
Molecular Weight: 258.23 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC)
Storage: -20°C in dry conditions

2. Key Applications

5-Methyluridine is essential in:

RNA modification studies and nucleotide research
Pharmaceutical intermediates for antiviral drug development
Diagnostic reagent formulation
Oligonucleotide synthesis and mRNA vaccine production

3. Usage Guidelines

Handling Procedures

Reconstitute in nuclease-free water at 10 mM concentration
Maintain sterile conditions for biological applications
Use anhydrous DMSO for solubility challenges
Store working solutions at -80°C for long-term stability

Safety Precautions

Use PPE: gloves, lab coat, and eye protection
Avoid inhalation or direct skin contact
Dispose per local chemical waste regulations

4. Practical Use Cases

Case Study 1: mRNA Vaccine Stability Enhancement

Researchers incorporated 5-Methyluridine at 0.5 mM concentration in mRNA-LNP formulations, resulting in:

15% improvement in thermal stability
Extended shelf life by 3 months at 4°C
Enhanced translation efficiency in vivo

Case Study 2: Antiviral Drug Development

Used as precursor in synthesis of broad-spectrum antiviral compounds:

20% yield improvement over traditional methods
Reduced cytotoxicity in mammalian cell lines

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This is William, CEO of Zhishang Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
2000 square R&D center
More than 20 research and development personnel,
12 sets of research and development equipment, 10 fume hoods and 6 university laboratories have been developed in cooperation
18 patents, 140 sets of chemical synthesis processes

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
For the United States, Australia, Japan, South Korea, Sweden, France, Spain and other global more than 2000 customers to provide high-quality products and services, has won the recognition and trust of customers in the industry.

More than 12 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

Mode of Transportation

By Air, fast but expensive.

By Sea, usual and economy.

By Train, suit for middle Asia countries.

FAQ

Does it support auditing?

Environmental Protection Science and Technology Park, Zhengfeng Road, High-tech Zone, Jinan City, Shandong Province

Whether to provide samples?

Free samples can be provided, and customers only need to pay the corresponding shipping costs

Delivery time

There are stock in the warehouse, and some products need to be customized for production within 3 working days, depending on the workshop situation and production schedule

What payment methods and currencies are accepted here?

We accept payment methods such as TT, Western Union, and letter of credit, etc. Meanwhile, we support currencies like US dollars, euros, RMB, and Bitcoin, etc.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Vivalr’s delivery rate is guaranteed to be 99.99%

2000+

square meter R&D center

12+

China(set) of R&D equipment

10+

Fume hood

20+

R&D team

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