Trimethylsilyl Cyanide, with the CAS number 7677 - 24 - 9, is a valuable chemical compound. Its molecular formula is C₄H₉NSi, and it has a molecular weight of approximately 99.21 g/mol. This compound appears as a colorless to slightly yellow liquid. It is soluble in common organic solvents such as ether, benzene, and toluene. Trimethylsilyl Cyanide is known for its high purity when supplied from the factory, meeting strict quality standards to ensure reliable performance in various applications.
Trimethylsilyl Cyanide has a wide range of applications in the chemical industry. One of the primary uses is in organic synthesis. It serves as a cyanide source for the introduction of the cyano group into organic molecules. This is crucial in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. For example, it can be used in the preparation of α - amino nitriles, which are important intermediates in the synthesis of amino acids and peptides. In the field of materials science, it can also be used in the modification of polymers to improve their chemical and physical properties.
When using Trimethylsilyl Cyanide, it is essential to follow strict safety protocols. First, always wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. The compound should be handled in a well - ventilated area, preferably under a fume hood, to avoid inhalation of harmful vapors. When measuring and transferring the product, use suitable glassware such as pipettes or syringes. It should be added slowly to the reaction mixture to control the reaction rate and prevent any potential violent reactions. After use, store the product in a cool, dry place away from sources of heat and ignition.
In a pharmaceutical research project, Trimethylsilyl Cyanide was used in the synthesis of a new anti - cancer drug. The researchers needed to introduce a cyano group into a specific organic molecule. They dissolved the reactant in an appropriate organic solvent in a round - bottom flask under an inert atmosphere. Then, they slowly added Trimethylsilyl Cyanide to the reaction mixture while stirring continuously. After a series of purification steps, they successfully obtained the desired intermediate with a high yield. This intermediate was then further modified to form the final anti - cancer drug. In another case, in the agrochemical industry, Trimethylsilyl Cyanide was used to synthesize a new type of insecticide. The compound was used to introduce a key functional group into the insecticide molecule, enhancing its efficacy against pests.
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