High Quality 3-Isobutyl-1-Methylxanthine CAS 28822-58-4: Product Guide
Table of Contents
1. Product Information
3-Isobutyl-1-Methylxanthine (CAS 28822-58-4) is a high-purity xanthine derivative widely used in biochemical and pharmaceutical research. Key specifications include:
- CAS Number: 28822-58-4
- Molecular Formula: C9H14N4O2
- Molecular Weight: 210.23 g/mol
- Appearance: White to off-white crystalline powder
- Purity: ≥98% (HPLC)
- Storage: Store at 2-8°C in a dry, dark environment
2. Product Uses
3-Isobutyl-1-Methylxanthine is primarily utilized in:
- Phosphodiesterase (PDE) Inhibition: Acts as a non-selective PDE inhibitor to elevate intracellular cAMP levels.
- Cell Culture Studies: Enhances differentiation in stem cell and adipocyte research.
- Drug Development: Used in studies targeting asthma, inflammation, and neurological disorders.
- In Vitro Diagnostics: Supports enzyme activity assays and signal transduction pathway analysis.
3. How to Use
- Solubility: Soluble in DMSO (50 mg/mL) and ethanol; slightly soluble in water.
- Dosage: Typical working concentrations range from 0.1-1.0 mM (optimize per experimental conditions).
- Safety: Wear PPE (gloves, lab coat, goggles) and work in a well-ventilated area.
- Storage: Keep sealed in original packaging to avoid moisture and light exposure.
4. Application Case Studies
Case Study 1: Adipocyte Differentiation
Researchers used 0.5 mM 3-Isobutyl-1-Methylxanthine in combination with insulin and dexamethasone to induce preadipocyte differentiation into mature adipocytes over 14 days, achieving 85% differentiation efficiency.
Case Study 2: Neurological Research
In Parkinson's disease models, 0.2 mM of this compound was applied to enhance dopamine receptor signaling, improving therapeutic outcomes in in vitro neuronal cultures.
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