1. Product Overview

3,5-Difluorophenylboronic Acid (CAS 156545-07-2) is a high-purity boronic acid derivative widely used in organic synthesis and pharmaceutical research. Key specifications include:

• Chemical Name: 3,5-Difluorophenylboronic Acid
• CAS Number: 156545-07-2
• Molecular Formula: C₆H₅BF₂O₂
• Molecular Weight: 157.91 g/mol
• Appearance: White to off-white crystalline powder
• Purity: ≥98% (HPLC)
• Storage: 2-8°C in a dry, airtight container

2. Applications of 3,5-Difluorophenylboronic Acid

This compound is a critical reagent in:

• Suzuki-Miyaura cross-coupling reactions for C-C bond formation
• Synthesis of fluorinated pharmaceutical intermediates
• Development of agrochemicals and advanced materials
• Preparation of bioactive molecules in drug discovery

3. Usage Guidelines

Handling Recommendations:

1. Use under inert atmosphere (N₂ or Ar) for moisture-sensitive reactions
2. Dissolve in polar aprotic solvents (e.g., THF, DMF) for optimal reactivity
3. Typical molar ratio: 1.0-1.2 equivalents relative to coupling partners
4. Monitor reaction progress via TLC or HPLC

Safety Precautions: Wear PPE (gloves, goggles) and avoid inhalation. In case of contact, rinse thoroughly with water.

4. Case Studies

Case 1: Synthesis of Fluorinated Biaryl Compounds

In a Suzuki coupling reaction:

• Reacted 3,5-Difluorophenylboronic Acid (1.1 eq) with 4-bromotoluene
• Catalyst: Pd(PPh₃)₄ (2 mol%)
• Base: K₂CO₃ (3 eq) in DMF/H₂O (3:1)
• Yield: 89% after 12h at 80°C

Case 2: Pharmaceutical Intermediate Preparation

Used in the synthesis of a tyrosine kinase inhibitor precursor:

• Reaction scale: 500g
• Purity of final intermediate: 99.2% (by NMR)
• Key advantage: Enhanced electron-withdrawing effect from fluorine substituents