1. Product Parameters

Product Name: Fmoc-L-Arg(Pbf)-OH

CAS Number: 154445-77-9

Molecular Formula: C₃₄H₃₈N₄O₇

Molecular Weight: 638.7 g/mol

Appearance: White to off-white powder

Purity: ≥95% (HPLC)

Storage: Store at -20°C in a dry, dark environment

2. Applications

Fmoc-L-Arg(Pbf)-OH is a critical reagent in solid-phase peptide synthesis (SPPS). Key applications include:

• Building block for introducing arginine residues into peptide chains.
• Protection of arginine side chains during synthesis (Pbf group prevents unwanted reactions).
• Widely used in pharmaceutical research, biotechnology, and academic studies for developing therapeutic peptides.

3. Usage Instructions

Step 1: Preparation

Equilibrate the compound to room temperature before use to avoid moisture absorption.

Step 2: Dissolution

Dissolve in dimethylformamide (DMF) or dichloromethane (DCM) at a concentration of 0.1-0.3 M.

Step 3: Coupling Reaction

Use coupling agents like HBTU or HATU (1:1 molar ratio) with a base (e.g., DIPEA) for 30-60 minutes.

Step 4: Deprotection

Remove the Fmoc group with 20% piperidine in DMF. The Pbf group remains intact until final cleavage.

4. Case Studies

Case Study 1: Antiviral Peptide Development

A research team utilized Fmoc-L-Arg(Pbf)-OH to synthesize a 15-mer peptide targeting viral envelope proteins. The Pbf group ensured side-chain stability during synthesis, achieving >90% purity post-HPLC.

Case Study 2: Cancer-Targeting Peptides

In a preclinical study, this reagent was employed to produce arginine-rich peptides for tumor penetration. The final product demonstrated enhanced cellular uptake in in vitro models.

5. Contact

For bulk orders or technical inquiries:

• Email: info@vivalr.com
• Phone: (86) 15866781826