Tert-Butyl Isocyanate (CAS 1609-86-5) - High-Quality Factory Supply
Table of Contents
1. Product Information
Tert-Butyl Isocyanate (CAS 1609-86-5) is a highly reactive chemical compound widely used in organic synthesis. Key specifications include:
- Chemical Formula: C5H9NO
- Molecular Weight: 99.13 g/mol
- Appearance: Colorless to pale yellow liquid
- Purity: ≥98%
- Storage: Store at 2-8°C in a cool, dry, and well-ventilated area. Keep away from light and moisture.
2. Applications
Tert-Butyl Isocyanate is a versatile intermediate in:
- Pharmaceuticals: Synthesis of active pharmaceutical ingredients (APIs) and drug intermediates.
- Agrochemicals: Production of herbicides, fungicides, and insecticides.
- Polymer Chemistry: Crosslinking agent for polyurethane foams, coatings, and adhesives.
- Research & Development: Building block for novel organic compounds.
3. Usage Guidelines
- Safety Precautions: Use in a fume hood with proper PPE (gloves, goggles, lab coat). Avoid inhalation, skin contact, or ingestion.
- Handling: Ensure airtight containers to prevent moisture absorption. Use dry syringes for measurement.
- Reaction Conditions: Typically reacts with amines, alcohols, or thiols under inert atmospheres (e.g., nitrogen). Optimal temperature: 0-25°C.
- Disposal: Follow local regulations for hazardous waste disposal.
4. Usage Case Studies
Case Study 1: Pharmaceutical Intermediate Synthesis
A pharmaceutical company used tert-butyl isocyanate to synthesize a key intermediate for an anti-cancer drug. Reaction with a primary amine at 20°C yielded a urea derivative with 92% purity after purification.
Case Study 2: Agrochemical Production
In the synthesis of a novel insecticide, tert-butyl isocyanate was reacted with a hydroxyl-containing substrate under catalytic conditions. The final product demonstrated enhanced stability and bioactivity.
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