Isosorbide Dimethyl Ether, also known as Dimethyl Isosorbide, has the CAS number 5306 - 85 - 4. It is a high - quality chemical product with excellent physical and chemical properties. In appearance, it is generally a clear and colorless liquid. The molecular formula of Isosorbide Dimethyl Ether is C8H14O4. Its molecular weight is approximately 174.19 g/mol. It has good solubility in a variety of organic solvents and shows stability under normal temperature and pressure conditions. The boiling point of this product is around 220 - 225 °C, and the density is about 1.12 g/cm³. These parameters make it a reliable chemical raw material in many industrial applications.
1. Cosmetics Industry: Isosorbide Dimethyl Ether is widely used in the cosmetics field. It can be used as a solvent, emollient, and carrier. It helps to dissolve other active ingredients in cosmetic formulations, such as vitamins, essential oils, and plant extracts. Its good skin - friendly properties make it suitable for skin - care products, including lotions, creams, and serums. It can improve the texture of the product, making it more spreadable and easier to absorb by the skin.
2. Pharmaceutical Industry: In the pharmaceutical sector, it can be used as a solvent for drugs. It can enhance the solubility and bioavailability of poorly soluble drugs. Moreover, it can be used as a penetration enhancer in topical drug delivery systems, helping drugs to penetrate the skin more effectively.
3. Chemical Synthesis: As an intermediate in chemical synthesis, Isosorbide Dimethyl Ether can participate in various chemical reactions to produce more complex organic compounds. It can be used in the synthesis of polymers, surfactants, and other fine chemicals.
When using Isosorbide Dimethyl Ether, proper safety precautions should be taken. It is recommended to wear appropriate personal protective equipment, such as gloves and safety glasses, to avoid direct contact with the skin and eyes.
1. For Cosmetics: In cosmetic formulations, it can be added during the mixing process. Usually, it is added in a proportion of 5% - 20% according to the specific requirements of the product. After adding, the mixture should be stirred well to ensure uniform dispersion.
2. For Pharmaceuticals: In pharmaceutical preparations, it is often used in combination with other solvents or excipients. The dosage should be determined according to the solubility and stability requirements of the drug. It is necessary to conduct compatibility tests to ensure that it does not affect the efficacy and quality of the drug.
3. For Chemical Synthesis: In chemical reactions, the amount of Isosorbide Dimethyl Ether used depends on the reaction stoichiometry and reaction conditions. It should be added slowly under appropriate temperature and stirring conditions to ensure the smooth progress of the reaction.
1. Cosmetic Case: A well - known skin - care brand developed a new anti - aging serum. By adding 15% Isosorbide Dimethyl Ether to the formula, the serum became more transparent and easier to spread. The active ingredients in the serum, such as retinol and hyaluronic acid, were better dissolved and absorbed by the skin. After a three - month trial by 100 volunteers, 80% of them reported that their skin became more hydrated, smoother, and showed a reduction in fine lines.
2. Pharmaceutical Case: A research team was developing a topical anti - inflammatory drug. Due to the poor solubility of the main drug ingredient, they added Isosorbide Dimethyl Ether as a penetration enhancer and solvent. After testing on animal models, it was found that the drug's transdermal absorption rate increased by 50% compared with the formulation without Isosorbide Dimethyl Ether, and the anti - inflammatory effect was significantly improved.
3. Chemical Synthesis Case: In a polymer synthesis experiment, Isosorbide Dimethyl Ether was used as an intermediate. By reacting with a specific monomer under certain reaction conditions, a new type of polymer material with good mechanical properties and biodegradability was successfully synthesized. This polymer has potential applications in packaging materials and biomedical fields.
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