Tebipenem Pivoxil (CAS 161715-24-8) is a broad-spectrum carbapenem antibiotic prodrug designed for oral administration. Key specifications include:
Tebipenem Pivoxil is clinically used to treat:
It demonstrates potent activity against Gram-positive, Gram-negative, and anaerobic pathogens, including β-lactamase-producing strains.
A 58-year-old patient with extended-spectrum β-lactamase (ESBL)-producing E. coli infection received 300 mg Tebipenem Pivoxil every 8 hours for 7 days. Clinical resolution occurred within 72 hours with no adverse effects.
In a multicenter trial, 120 children (6 months-12 years) with persistent otitis media received 6 mg/kg doses. 92% achieved clinical cure vs. 64% in comparator group (p<0.01).
Hospitalized patient with penicillin-resistant Streptococcus pneumoniae pneumonia showed 80% symptom improvement after 48 hours of 400 mg Tebipenem Pivoxil therapy.
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