5-Hexynoic Acid (CAS 53293-00-8) is an organic compound with the molecular formula C6H8O2 and a molecular weight of 112.13 g/mol. This alkyne-containing carboxylic acid appears as a clear to pale yellow liquid under standard conditions, with a melting point of 28-32°C and boiling point of 215-217°C. It is highly soluble in polar organic solvents like ethanol and dimethylformamide (DMF).
5-Hexynoic Acid serves as a critical building block in:
Researchers at ETH Zurich utilized 5-Hexynoic Acid as a linker in Remdesivir analogs, achieving 92% coupling efficiency in Suzuki-Miyaura cross-coupling reactions under mild conditions (60°C, 12h).
Dow Chemical incorporated the compound into polyaniline chains, enhancing electrical conductivity to 103 S/cm while maintaining thermal stability up to 280°C.
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