Hydroxypropyl-beta-cyclodextrin (HPBCD) is a chemically modified cyclic oligosaccharide. The product with CAS numbers 94035-02-6/128446-35-5 is a popular choice in various industries due to its unique properties.
Estructura química: HPBCD is derived from beta - cyclodextrin by substituting some of the hydroxyl groups with hydroxypropyl groups. This modification enhances its solubility and other functional properties compared to the unmodified beta - cyclodextrin.
Apariencia: It typically appears as a white, odorless, and free - flowing powder.
Solubilidad: One of the significant advantages of HPBCD is its high solubility in water. It can dissolve readily, even at relatively high concentrations, which makes it suitable for a wide range of applications.
Pureza: Our factory - supplied HPBCD has a high purity level, ensuring consistent performance in different applications.
Industria farmacéutica: HPBCD is widely used as a solubilizing agent in pharmaceuticals. It can form inclusion complexes with poorly soluble drugs, improving their solubility, bioavailability, and stability. This is particularly important for oral, parenteral, and topical drug formulations.
Industria alimentaria: In the food industry, HPBCD can be used as a flavor encapsulant. It can trap volatile flavor compounds, protecting them from oxidation, evaporation, and degradation. It also helps to improve the dispersion and stability of flavors in food products.
Industria cosmética: HPBCD can be incorporated into cosmetic formulations to enhance the solubility and stability of active ingredients. It can also improve the skin - feel of products and increase the effectiveness of certain cosmetic agents.
Química Analítica: It is used in analytical chemistry as a chiral selector in chromatography. HPBCD can separate enantiomers due to its unique molecular structure and chiral properties.
Solubilization in Pharmaceuticals: When using HPBCD to solubilize drugs, first, weigh the appropriate amount of HPBCD according to the solubility requirements of the drug. Then, add it to an aqueous solution under gentle stirring. Next, gradually add the drug to the solution and continue stirring until the drug is completely dissolved. The optimal ratio of HPBCD to the drug needs to be determined through pre - formulation studies.
Flavor Encapsulation in Food: For flavor encapsulation, dissolve HPBCD in water at an appropriate concentration. Add the flavor compound to the HPBCD solution under high - speed stirring. The flavor will be encapsulated within the HPBCD cavity. The encapsulated flavor can then be added to the food product during the manufacturing process.
Use in Cosmetics: In cosmetic formulations, HPBCD can be added to the water phase of the product. Heat the water phase to an appropriate temperature (usually around 60 - 70°C) and add HPBCD with stirring until it is completely dissolved. Then, add other ingredients as per the formulation requirements.
Pharmaceutical Case: A pharmaceutical company was developing an oral drug with poor solubility. By using HPBCD as a solubilizing agent, they were able to increase the solubility of the drug by more than 10 - fold. This led to improved bioavailability in pre - clinical studies. Patients who took the new formulation showed better therapeutic responses compared to the original poorly soluble formulation.
Food Case: A food manufacturer wanted to enhance the stability of a fruit - flavored beverage. They used HPBCD to encapsulate the fruit flavor. After several months of storage, the flavor intensity in the beverage with HPBCD - encapsulated flavor remained significantly higher compared to the control beverage without encapsulation. The product also had a more consistent flavor profile over time.
Cosmetic Case: A cosmetic brand was formulating a new anti - aging serum. They incorporated HPBCD to improve the solubility of a key active ingredient. The serum showed better stability during storage, and in consumer trials, users reported better absorption and visible anti - aging effects compared to a similar serum without HPBCD.
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