The product we are introducing is High Quality panobinostat cas 404950 - 80 - 7 With Low Price. Panobinostat, with the CAS number 404950 - 80 - 7, is a well - known chemical compound in the pharmaceutical and research fields.
It is a potent histone deacetylase (HDAC) inhibitor. HDACs are enzymes that play a crucial role in the regulation of gene expression. By inhibiting HDACs, panobinostat can cause hyperacetylation of histones, which in turn can alter chromatin structure and gene transcription. This product is of high quality, ensuring stable performance and reliable results in various applications.
The product comes in a specific form, usually a powder, which has certain solubility characteristics. It is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), which is important for its subsequent use in experimental settings. The low price makes it an attractive option for researchers and institutions with budget constraints, without sacrificing the quality of the product.
Panobinostat has a wide range of uses, primarily in the field of medical research and drug development.
In cancer research, it has shown great potential. It can be used to study the mechanism of tumorigenesis. By inhibiting HDACs, it can induce cell cycle arrest, apoptosis, and differentiation of cancer cells. This makes it a promising candidate for the development of new anti - cancer drugs. Panobinostat has also been used in clinical trials for the treatment of multiple myeloma and other hematological malignancies. In these trials, it has demonstrated significant anti - tumor activity, either alone or in combination with other drugs.
Beyond cancer research, panobinostat is also used in epigenetic studies. Epigenetics is the study of heritable changes in gene expression that do not involve changes to the underlying DNA sequence. HDACs are key players in epigenetic regulation, and by using panobinostat, researchers can better understand the complex epigenetic mechanisms involved in various biological processes, such as development, aging, and neurodegenerative diseases.
When using High Quality panobinostat cas 404950 - 80 - 7, the following steps should be followed.
First, proper safety precautions must be taken. As with any chemical compound, it should be handled in a well - ventilated laboratory environment. Wear appropriate personal protective equipment, such as gloves, goggles, and a lab coat.
For in - vitro experiments, the powder should be dissolved in an appropriate solvent, such as DMSO, to prepare a stock solution. The concentration of the stock solution depends on the specific experimental requirements. Then, the stock solution can be diluted to the desired working concentration using the appropriate cell culture medium or buffer.
In in - vivo studies, the product needs to be formulated into a suitable dosage form, such as a suspension or solution, for administration to experimental animals. The dosage and administration route (e.g., oral, intravenous, intraperitoneal) should be carefully determined based on the experimental design and the characteristics of the animals.
Case 1: Cancer Cell Line Experiment
In a research project, scientists used panobinostat to study its effect on a human breast cancer cell line. They first prepared a 10 mM stock solution of panobinostat in DMSO. Then, they diluted the stock solution to various working concentrations (0.1 μM, 1 μM, and 10 μM) in the cell culture medium. After treating the breast cancer cells with these different concentrations of panobinostat for 48 hours, they observed significant changes in cell morphology. The cells showed signs of apoptosis, such as cell shrinkage and membrane blebbing. Flow cytometry analysis confirmed a dose - dependent increase in the apoptosis rate of the cancer cells, indicating the anti - cancer effect of panobinostat.
Case 2: In - Vivo Mouse Model
In another study, researchers used a mouse model of multiple myeloma. They formulated panobinostat into a suspension and administered it to the mice via oral gavage at a dosage of 5 mg/kg once a day for 2 weeks. After the treatment period, they found that the tumor volume in the treated mice was significantly smaller than that in the control group. Histological analysis of the tumor tissues showed increased apoptosis and decreased cell proliferation in the panobinostat - treated group, suggesting the potential therapeutic effect of panobinostat in the treatment of multiple myeloma.
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