Tetramethylpyrazine, with the CAS number 1124 - 11 - 4, is a well - known chemical compound. It has a molecular formula of C₈H₁₂N₂ and a molecular weight of approximately 136.19 g/mol. The compound appears as a white to light - yellow crystalline powder with a characteristic odor. It has good solubility in organic solvents such as ethanol, methanol, and chloroform, and is sparingly soluble in water. In terms of storage, it should be kept in a cool, dry place away from direct sunlight and sources of ignition. The melting point of Tetramethylpyrazine is around 83 - 86 °C, and its boiling point is approximately 199 - 201 °C.
Tetramethylpyrazine has a wide range of uses in different industries. In the pharmaceutical field, it has significant pharmacological activities. It can dilate blood vessels, improve microcirculation, and has anti - platelet aggregation effects. As a result, it is often used in the treatment of cardiovascular and cerebrovascular diseases, such as cerebral thrombosis, myocardial infarction, and angina pectoris.
In the food industry, Tetramethylpyrazine is used as a flavoring agent. It has a unique nutty and roasted aroma, which can enhance the flavor of food products. It is commonly added to meat products, sauces, and snacks to provide a rich and savory taste.
In the chemical synthesis field, it serves as an important intermediate for the synthesis of various organic compounds. Its structure can be modified to produce new compounds with different properties and functions.
When used in the pharmaceutical industry, the dosage of Tetramethylpyrazine should be strictly controlled according to the patient's condition and the doctor's advice. It can be formulated into different dosage forms, such as injections, tablets, and capsules. For injections, the concentration and injection rate need to be carefully adjusted to ensure safety and efficacy.
In the food industry, when using Tetramethylpyrazine as a flavoring agent, the recommended dosage is usually in the range of 0.01% - 0.1% of the total mass of the food product. It should be evenly mixed with other ingredients during the production process to ensure uniform flavor distribution.
In chemical synthesis, the reaction conditions, such as temperature, reaction time, and the amount of catalyst, need to be optimized according to the specific synthesis route. Usually, Tetramethylpyrazine is added to the reaction system under appropriate conditions to participate in the reaction.
Case 1: In a clinical trial for the treatment of cerebral thrombosis, a group of patients were administered Tetramethylpyrazine injections. After a course of treatment, the patients showed significant improvement in neurological function. The blood circulation in the affected area was improved, and the symptoms of hemiplegia and speech impairment were alleviated. The patients' quality of life was greatly enhanced, and the recurrence rate was also reduced.
Case 2: A well - known food company added Tetramethylpyrazine to its new line of meat snacks. The product immediately gained popularity among consumers due to its rich and unique flavor. The sales volume increased by 30% compared to the previous similar products without Tetramethylpyrazine.
Case 3: In a chemical research project, Tetramethylpyrazine was used as an intermediate to synthesize a new type of anti - cancer compound. Through a series of chemical reactions, a compound with high anti - cancer activity was successfully obtained. The new compound showed good inhibitory effects on cancer cells in in - vitro experiments.
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