3′-Hydroxyacetophenone (CAS 121-71-1) is an organic compound with the molecular formula C8H8O2 and a molecular weight of 136.15 g/mol. This white to pale-yellow crystalline powder boasts a purity of ≥98% (HPLC) and is packaged in moisture-proof, sealed containers (1kg, 5kg, 25kg options). Key specifications include:
3′-Hydroxyacetophenone serves as a critical intermediate in:
In the production of antihypertensive drug candidates, 3′-Hydroxyacetophenone undergoes Friedel-Crafts acylation with chloroacetyl chloride at 0-5°C, followed by catalytic hydrogenation to yield key intermediates with 82% average yield.
Used in a 3-step synthesis of herbicide Protoporphyrinogen oxidase inhibitors:
1. Etherification with 2,4-dichlorophenol (molar ratio 1:1.2)
2. Sulfonation at 80°C for 4hrs
3. Final purification via column chromatography (hexane/ethyl acetate 3:1)
Blended with linalool and coumarin in ethanol (1:0.5:0.3 ratio) to create long-lasting floral fragrance bases for premium cosmetics.
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