1. Product Overview

Product Name: Pyridine-3-sulfonyl chloride

CAS Number: 16133-25-8

Molecular Formula: C₅H₄ClNO₂S

Molecular Weight: 177.61 g/mol

Appearance: White to light yellow crystalline powder

Purity: ≥98% (HPLC)

Storage: Keep in a cool, dry place under inert atmosphere

2. Applications

Pyridine-3-sulfonyl chloride is a versatile intermediate widely used in:

• Pharmaceuticals: Synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemicals: Production of herbicides, fungicides, and pesticides.
• Material Science: Modification of polymers and specialty chemicals.
• Research & Development: Building block for organic synthesis and cross-coupling reactions.

3. Usage Instructions

Safety Precautions

• Wear PPE (gloves, goggles, lab coat) to avoid skin/eye contact.
• Use in a well-ventilated area or under a fume hood.
• Avoid moisture and incompatible substances (e.g., strong bases).

Handling & Storage

• Store at 2-8°C in sealed, moisture-proof containers.
• Handle under nitrogen or argon to prevent hydrolysis.

4. Detailed Use Cases

Case 1: Synthesis of Antiviral Agents

Pyridine-3-sulfonyl chloride is reacted with amines to form sulfonamide derivatives, a key step in producing antiviral drugs. For example:

1. Dissolve 1 mmol of the amine in dry dichloromethane.
2. Add 1.2 mmol of pyridine-3-sulfonyl chloride dropwise at 0°C.
3. Stir for 4 hours at room temperature, then purify via column chromatography.

Case 2: Herbicide Intermediate

Used to synthesize sulfonylurea herbicides by reacting with carbamates under basic conditions, achieving >90% yield.

5. Contact Information

For technical inquiries or bulk orders:

• Email: info@vivalr.com
• Phone: (86) 15866781826