The product we offer is Factory Supply Ruxolitinib with CAS number 941678-49-5. Ruxolitinib is a small molecule Janus kinase (JAK) 1 and JAK2 inhibitor. Its chemical formula is C17H18N6, and the molecular weight is approximately 306.37 g/mol. This product is presented in a high - quality form, sourced directly from the factory, ensuring reliable quality and a competitive price.
Ruxolitinib has significant medical applications. It is primarily used in the treatment of myelofibrosis, a rare type of bone marrow cancer. By inhibiting JAK1 and JAK2 kinases, it can reduce the abnormal signaling pathways that drive the growth of cancer cells, alleviate symptoms such as splenomegaly, and improve patients' quality of life. Additionally, it has shown potential in the treatment of polycythemia vera, a blood disorder characterized by excessive production of red blood cells. In dermatology, Ruxolitinib has also been explored for the treatment of alopecia areata, as it may modulate the immune response in the scalp area.
The use of Ruxolitinib should be strictly under the guidance of a medical professional. For oral administration, the typical dosage for myelofibrosis patients may start at 15 mg or 20 mg twice a day, depending on the patient's platelet count. The dosage should be adjusted according to the patient's response and tolerance. It is recommended to take the medicine with food to enhance absorption and reduce the risk of gastrointestinal discomfort. Close monitoring of blood counts and other relevant indicators is necessary during the treatment process to ensure the safety and effectiveness of the treatment.
Case 1: Mr. Smith, a 60 - year - old male, was diagnosed with myelofibrosis. He started taking Ruxolitinib at a dosage of 15 mg twice a day. After 3 months of treatment, his splenomegaly was significantly reduced, and his symptoms such as fatigue and abdominal discomfort were also alleviated. His blood counts gradually returned to a more normal range, and he was able to resume his normal daily activities.
Case 2: Ms. Johnson, a 45 - year - old female with polycythemia vera, was prescribed Ruxolitinib. Initially, she took 20 mg twice a day. Over time, her hematocrit levels decreased to a more acceptable level, and she no longer needed frequent phlebotomies. Her overall well - being improved, and she reported a reduction in headaches and dizziness associated with the disease.
Case 3: In a dermatology study, a patient with severe alopecia areata was treated with a topical formulation of Ruxolitinib. After several months of treatment, significant hair regrowth was observed in the affected areas, which restored the patient's confidence.
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