Titanocene dichloride, with the CAS number 1271-19-8, is a well - known organometallic compound. It has a molecular formula of C10H10Cl2Ti. The compound appears as a bright red crystalline solid. It has a molar mass of approximately 248.96 g/mol.
The melting point of titanocene dichloride is around 287 - 289 °C. It is sparingly soluble in water but can dissolve in some organic solvents such as dichloromethane, toluene, and diethyl ether. This solubility property allows it to be used in a variety of chemical reactions carried out in organic media.
Titanocene dichloride has several important applications in different fields. In organic synthesis, it serves as a powerful catalyst. It can catalyze a wide range of reactions, including the reduction of carbon - carbon double bonds and the formation of carbon - carbon bonds. For example, it can be used in the synthesis of complex organic molecules with specific stereochemistry, which is crucial in the pharmaceutical and agrochemical industries.
Another significant use is in materials science. Titanocene dichloride can be incorporated into polymer matrices to modify their properties. It can improve the thermal stability, mechanical strength, and electrical conductivity of polymers, making them suitable for use in high - tech applications such as electronic devices and aerospace components.
When using titanocene dichloride, it is essential to handle it with care. Since it is a chemical compound, proper laboratory safety procedures should be followed. Always wear appropriate personal protective equipment, including gloves, goggles, and a lab coat.
For catalytic reactions, the compound should be accurately weighed and added to the reaction mixture under an inert atmosphere, usually nitrogen or argon, to prevent oxidation. The reaction conditions, such as temperature, reaction time, and solvent choice, need to be carefully controlled according to the specific reaction requirements.
When incorporating it into polymers, it is typically dissolved in a suitable organic solvent first. Then, this solution is added to the polymer precursor solution. The mixture is then processed through various methods such as casting, extrusion, or molding to form the final polymer - titanocene dichloride composite.
Case 1: Pharmaceutical Synthesis
In a project to synthesize a new anti - cancer drug, titanocene dichloride was used as a catalyst. The reaction aimed to form a specific carbon - carbon bond in the drug molecule. By using titanocene dichloride under appropriate reaction conditions (reaction temperature of 60 °C in toluene for 12 hours), the desired product was obtained with a high yield of 85%. The reaction was highly selective, which was crucial for the purity of the final drug product.
Case 2: Polymer Modification
A research team aimed to improve the mechanical properties of a common polymer, polyethylene. They dissolved titanocene dichloride in dichloromethane and added it to the polyethylene precursor solution. After processing the mixture through extrusion, the resulting composite showed a 30% increase in tensile strength compared to the pure polyethylene. This improvement made the composite more suitable for use in automotive parts.
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