Artesunate with the CAS number 88495 - 63 - 0 is a high - quality product available at the best price. It is a semi - synthetic derivative of artemisinin, which is extracted from the plant Artemisia annua. The molecular formula of artesunate is C₂₃H₃₂O₁₀, and its molecular weight is approximately 468.49 g/mol. It appears as a white to off - white powder. Artesunate is highly soluble in methanol and ethanol and slightly soluble in water. It has a melting point range of around 160 - 162°C. High - quality artesunate should meet strict quality control standards, ensuring its purity, stability, and effectiveness.
Artesunate is primarily used in the treatment of malaria. Malaria is a life - threatening mosquito - borne blood disease caused by Plasmodium parasites. Artesunate works by killing the malaria parasites in the blood, thus helping to relieve the symptoms and cure the disease. It is especially effective against Plasmodium falciparum, the most dangerous malaria parasite species. In addition to malaria treatment, artesunate has also shown potential in other areas. Some research suggests that it may have anti - cancer properties. It can induce apoptosis (programmed cell death) in cancer cells and inhibit tumor growth. However, more extensive research is needed in this field to fully understand its mechanisms and applications.
The usage of artesunate depends on several factors, including the patient's age, weight, and the severity of the malaria infection. For malaria treatment, artesunate is usually administered either orally, intravenously, or intramuscularly. In a hospital setting, intravenous or intramuscular administration is often preferred for severe malaria cases to ensure a rapid effect. The dosage is typically calculated according to the patient's body weight. For example, in some treatment regimens, an initial dose of 2.4 mg/kg body weight is given, followed by the same dose at 12 and 24 hours, and then once daily. When using artesunate, it is crucial to follow the doctor's instructions carefully. Do not adjust the dosage or stop the treatment prematurely, as this may lead to treatment failure and the development of drug - resistant malaria.
Case 1: A 35 - year - old male patient was admitted to the hospital with severe malaria caused by Plasmodium falciparum. He presented with high fever, chills, headache, and fatigue. The doctor immediately started him on an intravenous artesunate treatment. The initial dose was 2.4 mg/kg based on his body weight of 70 kg. After 12 hours, another dose of 2.4 mg/kg was administered, followed by the same dose at 24 hours. By the third day of treatment, the patient's fever had subsided, and the malaria parasites in his blood had significantly decreased. After a full course of treatment, the patient fully recovered, and follow - up blood tests showed no presence of malaria parasites.
Case 2: In a malaria - endemic region, a 10 - year - old child was diagnosed with uncomplicated malaria. The doctor prescribed oral artesunate at a dosage adjusted for the child's weight. The child took the medication as directed for three days. By the end of the treatment, the child's symptoms such as fever and weakness had disappeared. A follow - up visit a week later confirmed that the malaria infection had been successfully treated.
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