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4-Pyrimidinamine, 5-(Bromomethyl)-2-methyl-, Monohydrobromide (CAS 2908-71-6) User Guide

1. Product Information

Product Name: 4-Pyrimidinamine, 5-(Bromomethyl)-2-methyl-, Monohydrobromide

CAS Number: 2908-71-6

Molecular Formula: C₆H₈BrN₃·HBr

Molecular Weight: 289.97 g/mol

Purity: ≥98% (HPLC)

Appearance: White to off-white crystalline powder

Storage: Store at room temperature, protected from light and moisture.

2. Intended Use

This compound is a high-purity brominated pyrimidine derivative primarily used as a pharmaceutical intermediate in the synthesis of antiviral and anticancer agents. Its reactive bromomethyl group makes it ideal for cross-coupling reactions and functionalization in organic chemistry. It is widely employed in research laboratories and industrial settings for drug discovery and development.

3. Usage Guidelines

Safety Precautions: Wear PPE (gloves, goggles, lab coat). Avoid inhalation or direct contact. Use in a well-ventilated fume hood.

Solubility: Soluble in DMSO, ethanol, and dimethylformamide (DMF).

Handling: Stabilize at room temperature before use. For prolonged storage, keep under inert gas (e.g., nitrogen).

Reaction Conditions: Typical use concentration: 0.1-1.0 mM. Optimal reaction temperature: 20-40°C.

4. Application Case Studies

Case Study 1: Antiviral Drug Intermediate Synthesis

In a 2023 study, CAS 2908-71-6 was used to synthesize a novel nucleoside analog for hepatitis B treatment. The bromomethyl group facilitated selective alkylation at the pyrimidine N1 position, achieving a 78% yield under mild conditions (pH 7.4, 25°C).

Case Study 2: Kinase Inhibitor Development

Researchers utilized this compound to create a potent kinase inhibitor for non-small cell lung cancer. The bromine atom enabled efficient Suzuki-Miyaura coupling with boronic acid partners, enhancing binding affinity by 3x compared to chloro analogs.

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The Manager has Something to Say

This is William, CEO of Zhishang Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
2000 square R&D center
More than 20 research and development personnel,
12 sets of research and development equipment, 10 fume hoods and 6 university laboratories have been developed in cooperation
18 patents, 140 sets of chemical synthesis processes

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
For the United States, Australia, Japan, South Korea, Sweden, France, Spain and other global more than 2000 customers to provide high-quality products and services, has won the recognition and trust of customers in the industry.

More than 12 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

Mode of Transportation

By Air, fast but expensive.

By Sea, usual and economy.

By Train, suit for middle Asia countries.

FAQ

Does it support auditing?

Environmental Protection Science and Technology Park, Zhengfeng Road, High-tech Zone, Jinan City, Shandong Province

Whether to provide samples?

Free samples can be provided, and customers only need to pay the corresponding shipping costs

Delivery time

There are stock in the warehouse, and some products need to be customized for production within 3 working days, depending on the workshop situation and production schedule

What payment methods and currencies are accepted here?

We accept payment methods such as TT, Western Union, and letter of credit, etc. Meanwhile, we support currencies like US dollars, euros, RMB, and Bitcoin, etc.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Vivalr’s delivery rate is guaranteed to be 99.99%

2000+

square meter R&D center

12+

China(set) of R&D equipment

10+

Fume hood

20+

R&D team

User’evaluation of us

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