The product in question is High Quality boc-O-benzyl-l-threonine with the CAS number 15260 - 10 - 3. The CAS number serves as a unique identifier for this chemical compound in the scientific community.
Chemically, boc - O - benzyl - l - threonine is an amino acid derivative. The "boc" group (tert - butyloxycarbonyl) is a common protecting group in organic synthesis, which is useful for protecting the amino group during chemical reactions. The "O - benzyl" group is attached to the hydroxyl group of the threonine residue. The "l" configuration indicates the stereochemistry of the amino acid, which follows the natural configuration found in most proteins.
In terms of quality, it is emphasized as being of high quality, which implies that it has a high degree of purity. This high - purity product is likely to have less impurities, which is crucial for applications in research and chemical synthesis where impurities can interfere with reactions and results.
1. **Peptide Synthesis**: One of the primary uses of boc - O - benzyl - l - threonine is in peptide synthesis. Peptides are short chains of amino acids, and this compound can be incorporated into peptide chains during solid - phase or solution - phase peptide synthesis. The boc group can be selectively removed under specific reaction conditions, allowing for the step - by - step addition of other amino acids to form the desired peptide sequence.
2. **Medicinal Chemistry**: In the field of medicinal chemistry, it can be used as a building block for the synthesis of potential drug candidates. By modifying the structure of boc - O - benzyl - l - threonine or incorporating it into larger molecules, researchers can design and synthesize compounds with specific biological activities, such as enzyme inhibitors or receptor ligands.
3. **Biochemical Research**: It can also be used in biochemical research to study the function and structure of proteins and peptides. For example, it can be used to label or modify specific amino acid residues in proteins to investigate their role in biological processes.
1. **Storage**: Store the product in a cool, dry place away from direct sunlight and sources of heat. Keep it in a tightly sealed container to prevent moisture and air from entering, as these can potentially degrade the compound over time.
2. **Handling**: When handling boc - O - benzyl - l - threonine, it is recommended to wear appropriate personal protective equipment, such as gloves and safety glasses. Avoid inhalation, ingestion, and contact with skin and eyes. In case of contact, immediately rinse the affected area with plenty of water and seek medical advice if necessary.
3. **Reaction Conditions**: In peptide synthesis, the boc group can be removed using an acidic reagent, such as trifluoroacetic acid (TFA). The reaction conditions, including the concentration of the reagent, reaction temperature, and reaction time, need to be carefully controlled to ensure the efficient removal of the boc group without affecting other parts of the molecule.
**Case 1: Synthesis of a Bioactive Peptide**
A research group aimed to synthesize a bioactive peptide with potential anti - inflammatory properties. They used boc - O - benzyl - l - threonine as one of the building blocks in solid - phase peptide synthesis. First, the resin was functionalized with the first amino acid. Then, boc - O - benzyl - l - threonine was coupled to the growing peptide chain using a coupling reagent, such as N,N' - dicyclohexylcarbodiimide (DCC). After several cycles of coupling and deprotection steps, the desired peptide was successfully synthesized. In vitro tests showed that the synthesized peptide had significant anti - inflammatory effects on immune cells.
**Case 2: Medicinal Chemistry Research**
Another team of researchers was interested in developing a new class of enzyme inhibitors. They incorporated boc - O - benzyl - l - threonine into the structure of a lead compound. By modifying the side chains and functional groups around the boc - O - benzyl - l - threonine residue, they were able to optimize the binding affinity and selectivity of the compound towards the target enzyme. Inhibition assays demonstrated that the optimized compound had potent inhibitory activity against the enzyme, suggesting its potential as a therapeutic agent.
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