Factory Supply Trifluoroacetic anhydride/TFAA with CAS number 407 - 25 - 0 is a high - quality chemical product offered at a low price. Its chemical formula is (CF₃CO)₂O. It is a colorless to slightly yellowish liquid with a pungent odor. The molecular weight of TFAA is approximately 210.03 g/mol. It has a boiling point of around 40 - 41°C at 760 mmHg and a density of about 1.489 g/cm³ at 25°C. TFAA is highly reactive due to the presence of the trifluoroacetyl groups, which makes it a valuable reagent in organic synthesis.
1. Organic Synthesis: TFAA is widely used in organic chemistry as an acylating agent. It can be used to introduce trifluoroacetyl groups into various organic compounds, which can change the physical and chemical properties of the original molecules. For example, it can be used in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals.
2. Protective Group Chemistry: In peptide synthesis, TFAA can be used to remove certain protective groups, enabling the controlled synthesis of peptides with specific sequences and structures.
3. Catalyst in Reactions: It can also act as a catalyst in some organic reactions, promoting the reaction rate and improving the yield of the desired products.
1. Storage: TFAA should be stored in a cool, dry, and well - ventilated area. It should be kept away from heat sources, open flames, and incompatible substances such as strong bases and reducing agents. The container should be tightly sealed to prevent leakage.
2. Handling: When handling TFAA, appropriate personal protective equipment (PPE) should be worn, including safety glasses, chemical - resistant gloves, and a lab coat. It should be handled in a fume hood to avoid inhalation of the pungent fumes.
3. Reaction Setup: In a reaction, TFAA is usually added slowly to the reaction mixture under appropriate temperature and stirring conditions. The reaction conditions, such as temperature, reaction time, and the ratio of reactants, need to be carefully controlled according to the specific reaction requirements.
Case 1: Pharmaceutical Synthesis
A pharmaceutical company was synthesizing a new anti - inflammatory drug. They used TFAA as an acylating agent to introduce a trifluoroacetyl group into an intermediate compound. By carefully controlling the reaction conditions, they were able to achieve a high yield of the desired intermediate. The reaction was carried out in an organic solvent at a temperature of 0 - 5°C for 2 hours. After purification, the intermediate was further reacted to form the final drug product. The use of TFAA not only improved the reaction efficiency but also enhanced the biological activity of the final drug.
Case 2: Peptide Synthesis
In a peptide synthesis laboratory, TFAA was used to remove a specific protective group from a peptide fragment. The peptide was dissolved in a suitable solvent, and TFAA was added drop - wise under an inert gas atmosphere. After a certain reaction time, the protective group was successfully removed, and the peptide could be further coupled with other fragments to form a longer peptide chain. The use of TFAA in this process was crucial for the accurate and efficient synthesis of the target peptide.
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