The product we are introducing is High Quality levosimendan with the CAS number 141505 - 33 - 1. Levosimendan is a novel calcium - sensitizing inodilator. It has high purity and is offered at a very competitive price, which makes it an attractive choice for various applications. The chemical formula of levosimendan is C13H13N7O, and its molecular weight is approximately 283.29 g/mol. It appears as a white to off - white crystalline powder. The product is carefully manufactured under strict quality control standards to ensure its high quality and stability.
Levosimendan is mainly used in the medical field. It is administered intravenously. Before use, it should be properly diluted according to the prescribed concentration. The dilution process should be carried out in a sterile environment to avoid contamination. The dosage needs to be determined by a professional medical staff based on the patient's condition, such as the severity of heart failure, age, and overall health status. Generally, the initial loading dose may range from 6 to 12 μg/kg over 10 minutes, followed by a continuous infusion at a rate of 0.05 - 0.2 μg/kg/min. During the use of levosimendan, patients should be closely monitored for vital signs, including blood pressure, heart rate, and electrocardiogram.
The main application of levosimendan is in the treatment of acute decompensated heart failure. It works by increasing the sensitivity of cardiac myofilaments to calcium without increasing intracellular calcium concentration. This mechanism not only enhances myocardial contractility but also reduces myocardial oxygen consumption. In addition to improving cardiac function, levosimendan can also cause vasodilation, which helps to relieve the workload of the heart. It has been shown to improve symptoms such as shortness of breath, fatigue, and fluid retention in patients with heart failure. Moreover, it may also have a positive impact on long - term prognosis in some cases.
Case 1: A 65 - year - old male patient was admitted to the hospital with acute decompensated heart failure. He had a history of coronary artery disease and previous myocardial infarction. His symptoms included severe shortness of breath at rest, orthopnea, and peripheral edema. After the administration of levosimendan, with an initial loading dose of 8 μg/kg over 10 minutes followed by a continuous infusion at 0.1 μg/kg/min for 24 hours, the patient's symptoms improved significantly. His shortness of breath decreased, and he was able to lie flat without discomfort. Echocardiogram showed an improvement in left ventricular ejection fraction from 25% to 35%.
Case 2: A 58 - year - old female patient with dilated cardiomyopathy presented with worsening heart failure symptoms. She had fatigue, decreased exercise tolerance, and abdominal distension due to ascites. Levosimendan was administered following the standard protocol. After the treatment, her exercise tolerance increased, and the ascites gradually resolved. Her quality of life improved, and she was able to resume her daily activities with less discomfort.
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This is William, CEO of Zhishang Chemical Co., Ltd.
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