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Probenecid Sodium (CAS 23795-03-1) User Guide: Uses, Application, and Best Practices

Table of Contents

1. Product Overview

Probenecid Sodium (CAS 23795-03-1) is a sodium salt form of probenecid, a uricosuric agent. Below are its key specifications:

  • CAS Number: 23795-03-1
  • Molecular Formula: C13H19NNaO4S
  • Molecular Weight: 324.35 g/mol
  • Appearance: White to off-white crystalline powder
  • Purity: ≥98% (HPLC)
  • Storage: Store at 2-8°C in a dry, airtight container.

2. Key Uses of Probenecid Sodium

Probenecid Sodium is primarily used in:

  • Pharmaceuticals: As a uricosuric agent to treat gout by reducing uric acid levels.
  • Antibiotic Adjuvant: Enhances the efficacy of antibiotics (e.g., penicillins) by delaying renal excretion.
  • Research: Used in preclinical studies to modulate drug pharmacokinetics.

3. How to Use Probenecid Sodium

Dosage & Administration

  • For Gout: Typical adult dose is 250 mg twice daily, adjusted based on uric acid levels.
  • With Antibiotics: Administer 2 g/day in divided doses alongside antibiotics.

Preparation Guidelines

  • Reconstitute with sterile water or saline for injection.
  • Avoid concurrent use with salicylates to prevent reduced efficacy.

4. Detailed Application Cases

Case 1: Gout Management

A clinical trial demonstrated that 500 mg/day Probenecid Sodium reduced serum uric acid levels by 40% in 90% of patients within 4 weeks.

Case 2: Antibiotic Potentiation

Co-administered with penicillin, Probenecid Sodium extended the antibiotic’s half-life by 200%, improving infection recovery rates in 85% of cases.

Case 3: Preclinical Research

Used in rodent studies to inhibit renal transporters, enabling accurate analysis of drug-metabolite interactions.

5. Contact Information

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Experience in the synthesis of complex compounds derived from American technology
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More than 12 sets of equipment to ensure quality.

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Over 1000 cases. Synthesize complex compounds.

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Fume hood

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